Stresses at the cell-to-substrate interface during locomotion of fibroblasts.

@article{Dembo1999StressesAT,
  title={Stresses at the cell-to-substrate interface during locomotion of fibroblasts.},
  author={Micah Dembo and Yvonne L. Wang},
  journal={Biophysical journal},
  year={1999},
  volume={76 4},
  pages={2307-16}
}
Recent technological improvements in the elastic substrate method make it possible to produce spatially resolved measurements of the tractions exerted by single motile cells. In this study we have applied these developments to produce maps of the tractions exerted by 3T3 fibroblasts during steady locomotion. The resulting images have a spatial resolution of approximately 5 micrometers and a maximum intensity of approximately 10(2) kdyn/cm2 (10(4) pN/micrometers2). We find that the propulsive… CONTINUE READING
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