Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity.

@article{Feng2001StressedAT,
  title={Stressed apoptotic tumor cells express heat shock proteins and elicit tumor-specific immunity.},
  author={Hanping Feng and Yi Zeng and Luke Whitesell and Emmanuel Katsanis},
  journal={Blood},
  year={2001},
  volume={97 11},
  pages={3505-12}
}
In attempting to develop effective anticancer immunotherapies, the relative ability of apoptotic cells to induce an immune response remains an important but controversial consideration. A novel gene-transfer approach was used by which rapid induction of pure apoptosis can be selectively achieved in a transfected tumor cell population following exposure to a semisynthetic dimerizing ligand, AP20187. Inoculation of BALB/c mice with apoptotic and viable 12B1-D1 leukemia cells, at a 12:1 ratio… CONTINUE READING