Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells

@article{Kurata2008StressVP,
  title={Stress via p53 pathway causes apoptosis by mitochondrial Noxa upregulation in doxorubicin-treated neuroblastoma cells},
  author={Kenji Kurata and Ryu Yanagisawa and Miki Ohira and Masatoshi Kitagawa and Akira Nakagawara and Takehiko Kamijo},
  journal={Oncogene},
  year={2008},
  volume={27},
  pages={741-754}
}
In this study, we employed a panel of cell lines to determine whether p53-dependent cell death in neuroblastoma (NB) cells is caused by apoptotic cellular function, and we further studied the molecular mechanism of apoptosis induced via the p53-dependent pathway. We obtained evidence that a type of p53-dependent stress, doxorubicin (Doxo) administration, causes accumulation of p53 in the nucleus of NB cells and phosphorylation of several serine residues in both Doxo-sensitive and -resistant… CONTINUE READING

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