Stress-triggered abortion: inhibition of protective suppression and promotion of tumor necrosis factor-alpha (TNF-alpha) release as a mechanism triggering resorptions in mice.

@article{Arck1995StresstriggeredAI,
  title={Stress-triggered abortion: inhibition of protective suppression and promotion of tumor necrosis factor-alpha (TNF-alpha) release as a mechanism triggering resorptions in mice.},
  author={Petra Clara Arck and Fatima S Merali and J. Perez Manuel and G{\'e}rard Chaouat and David A. Clark},
  journal={American journal of reproductive immunology},
  year={1995},
  volume={33 1},
  pages={74-80}
}
PROBLEM Stress adversely affects pregnancy outcome and has been implicated as an abortogen in both animals and humans. However, the mechanisms whereby stress aborts are largely unknown. Alloimmunization can prevent stress-triggered abortion, and immunization is known to increase transforming growth factor-beta 2 (TGF-beta 2)-related suppressive activity. METHOD To investigate these mechanisms, DBA/2J males were mated to CBA/J or C3H/HeJ females, and the pregnant females were exposed to… CONTINUE READING