Stress-specific response of the p53-Mdm2 feedback loop

  title={Stress-specific response of the p53-Mdm2 feedback loop},
  author={Alexander Hunziker and Mogens H. Jensen and Sandeep Krishna},
  booktitle={BMC Systems Biology},
The p53 signalling pathway has hundreds of inputs and outputs. It can trigger cellular senescence, cell-cycle arrest and apoptosis in response to diverse stress conditions, including DNA damage, hypoxia and nutrient deprivation. Signals from all these inputs are channeled through a single node, the transcription factor p53. Yet, the pathway is flexible enough to produce different downstream gene expression patterns in response to different stresses. We construct a mathematical model of the… CONTINUE READING

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Realtime Evaluation of p53 Oscillatory Behavior In vivo Using Bioluminescent Imaging

  • DA Hamstra, MS Bhojani, LB Griffn, B Laxman, BD Ross, A Rehemtulla
  • Cancer Res
  • 2006
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