Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.

@article{DeFilippis2014StressSF,
  title={Stress signaling from human mammary epithelial cells contributes to phenotypes of mammographic density.},
  author={Rosa Anna DeFilippis and Colleen Augusta Fordyce and Kelley T Patten and Hang K Chang and Jianxin Zhao and Gerald V. Fontenay and Karla Kerlikowske and Bahram Parvin and Thea D. Tlsty},
  journal={Cancer research},
  year={2014},
  volume={74 18},
  pages={5032-5044}
}
Telomere malfunction and other types of DNA damage induce an activin A-dependent stress response in mortal nontumorigenic human mammary epithelial cells that subsequently induces desmoplastic-like phenotypes in neighboring fibroblasts. Some characteristics of this fibroblast/stromal response, such as reduced adipocytes and increased extracellular matrix content, are observed not only in tumor tissues but also in disease-free breast tissues at high risk for developing cancer, especially high… CONTINUE READING

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