Stress signaling and Myc downregulation: implications for cancer.

@article{Huang2004StressSA,
  title={Stress signaling and Myc downregulation: implications for cancer.},
  author={Zhongdong Huang},
  journal={Cell cycle},
  year={2004},
  volume={3 5},
  pages={
          593-6
        }
}
The transcription factor Myc forms a complex with its partner Max and with the regulatory DNA sequences on its target genes. Formation of this complex is required for Myc functions and Myc-induced oncogenic transformation. We have recently shown that formation of the Myc/Max/DNA complex is inhibited by the stress-responsive protein kinase Pak2 signaling pathway through phosphorylation of Myc. As a consequence of the phosphorylation, Myc loses its gene activation activity and the ability to… CONTINUE READING

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