High susceptibility to chronic social stress is associated with a depression-like phenotype
- Psychology, BiologyPsychoneuroendocrinology
How stress alters neural systems of reinforcement: A model of depressive etiology
- Psychology, Biology
A measure of how, and a possible mechanism by which, punishment information is internalized in stress reactivity and in the expression of MDD is identified: error and punishment signals are increasingly coupled with the salience of “bad” outcomes.
Decreased Adrenocorticotropic Hormone and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
- Psychology, MedicineBiological Psychiatry
Decreased ACTH and Cortisol Responses to Stress in Healthy Adults Reporting Significant Childhood Maltreatment
- Psychology, Medicine
In adults without diagnosable psychopathology, childhood maltreatment is associated with diminished HPA axis response to a psychosocial stressor.
Depression during pregnancy and postpartum: Contribution of stress and ovarian hormones
- Psychology, BiologyProgress in Neuro-Psychopharmacology and Biological Psychiatry
Mice selected for high versus low stress reactivity: A new animal model for affective disorders
- Biology, PsychologyPsychoneuroendocrinology
Higher comorbidity of depression and cardiovascular disease in women: A biopsychosocial perspective
- PsychologyThe world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
There is considerable evidence that greater exposure to chronic stressors in women, interpersonal stress responsiveness, and internalizing coping styles are associated with an elevated risk of CVD and/or depression through behavioural and pathophysiological mechanisms including alterations in HPA axis functioning and autonomic nervous system which appear to be specific for women.
Cognitive impairments, emotion, stress, and language in schizophrenia
- PsychologyPsychiatry Research
Selectively bred rodents as models of depression and anxiety.
- Biology, PsychologyCurrent topics in behavioral neurosciences
Existing rodent models for research in psychiatry are summarized to elucidate the etiology and pathophysiology of anxiety and affective disorders, and to assist in the development of new treatment paradigms.
Rumination predicts heightened responding to stressful life events in major depressive disorder and generalized anxiety disorder.
- PsychologyJournal of abnormal psychology
Stress-related rumination was more deleterious for diagnosed than healthy individuals, more intense for more severe clinical cases, and more persistent for cases with a greater temperamental vulnerability for emotional disorders.
SHOWING 1-10 OF 61 REFERENCES
The role of corticotropin-releasing factor in depression and anxiety disorders.
- Psychology, BiologyThe Journal of endocrinology
The hypothesis that CRF receptor antagonists may represent a novel class of antidepressants and/or anxiolytics, probably through its effects on central noradrenergic systems, is supported.
Increased Depression-Like Behaviors in Corticotropin-Releasing Factor Receptor-2-Deficient Mice: Sexually Dichotomous Responses
- Psychology, BiologyThe Journal of Neuroscience
The results may reveal an interaction of CRF pathways with other known antidepressant systems and may also support an involvement ofCRF receptors in the development of depression such that elevated CRFR1 activity, in the absence of CRFR2, increases depression-like behaviors.
Sex differences and the HPA axis: implications for psychiatric disease.
- PsychologyThe journal of gender-specific medicine : JGSM : the official journal of the Partnership for Women's Health at Columbia
The data presented suggest that greater stress responsive in women may be influenced by ovarian steroids, and this greater stress responsiveness and resistance to glucocorticoid feedback may be one biological factor contributing to the greater incidence of depression in women.
Psychopathology in women and men: focus on female hormones.
- Psychology, MedicineThe American journal of psychiatry
Estrogens are neuroprotective with respect to neuronal degeneration, growth, and susceptibility to toxins, and the cyclic fluctuations of estrogens and progesterone enhance the response to stress, which confers susceptibility to depression and anxiety.
The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety.
- Biology, PsychologyJournal of psychiatric research
INDUCTION OF CORTICOTROPIN-RELEASING HORMONE GENE EXPRESSION BY GLUCOCORTICOIDS: IMPLICATION FOR UNDERSTANDING THE STATES OF FEAR AND ANXIETY AND ALLOSTATIC LOAD
- Biology, PsychologyPsychoneuroendocrinology
Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects.
- Biology, MedicineJournal of psychiatric research
CRF and CRF receptors: role in stress responsivity and other behaviors.
- Biology, PsychologyAnnual review of pharmacology and toxicology
Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR1, specific actions of UcnII and UcnIII on CRFR2 may be important for dampening stress sensitivity.