Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals.

@article{Kohno2010StresssensingMI,
  title={Stress-sensing mechanisms in the unfolded protein response: similarities and differences between yeast and mammals.},
  author={Kenji Kohno},
  journal={Journal of biochemistry},
  year={2010},
  volume={147 1},
  pages={27-33}
}
The unfolded protein response is an adaptive stress response that responds to the imbalance between the entry of newly synthesized unfolded proteins and the inherent folding capacity in the endoplasmic reticulum (ER). Various environmental stresses and changes in physiological conditions can result in the accumulation of unfolded proteins in the ER, which is sensed through ER transmembrane protein sensors named inositol requiring enzyme 1 (IRE1), PKR-like ER kinase (PERK) and activating… CONTINUE READING

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