Stress responses: the contribution of prostaglandin E2 and its receptors

@article{Furuyashiki2011StressRT,
  title={Stress responses: the contribution of prostaglandin E2 and its receptors},
  author={Tomoyuki Furuyashiki and Shuh Narumiya},
  journal={Nature Reviews Endocrinology},
  year={2011},
  volume={7},
  pages={163-175}
}
Stress is a state of physiological or psychological strain caused by adverse stimuli; responses to stress include activation of the sympathetic nervous system, glucocorticoid secretion and emotional behaviors. Prostaglandin E2 (PGE2), acting through its four receptor subtypes (EP1, EP2, EP3 and EP4), is involved in these stress responses. Studies of EP-selective drugs and mice lacking specific EPs have identified the neuronal pathways regulated by PGE2. In animals with febrile illnesses, PGE2… Expand
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