Stress resistance and aging: influence of genes and nutrition.

  title={Stress resistance and aging: influence of genes and nutrition.},
  author={James M. Harper and Adam B Salmon and Yayi Chang and Michael Bonkowski and Andrzej Bartke and Richard L. Miller},
  journal={Mechanisms of ageing and development},
  volume={127 8},
Previous studies have shown that dermal fibroblast cell lines derived from young adult mice of the long-lived Snell dwarf (dw/dw), Ames dwarf (df/df) and growth hormone receptor knockout (GHR-KO) mouse stocks are resistant, in vitro, to the cytotoxic effects of hydrogen peroxide, cadmium, ultraviolet light, paraquat, and heat. Here we show that, in contrast, fibroblasts from mice on low-calorie (CR) or low methionine (Meth-R) diets are not stress resistant in culture, despite the longevity… CONTINUE READING


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