Stress-related mucosal disease: risk factors and prophylactic therapy.

  title={Stress-related mucosal disease: risk factors and prophylactic therapy.},
  author={Mitchell J. Paul H. Gayle Felix W. Spirt},
  journal={Clinical therapeutics},
  volume={26 2},
BACKGROUND The term stress-related mucosal disease (SRMD) represents a continuum of conditions ranging from stress-related injury (superficial mucosal damage) to stress ulcers (focal deep mucosal damage). Caused by mucosal ischemia, SRMD is most commonly seen in critically ill patients in the intensive care unit (ICU). Prophylaxis of stress ulcers may reduce major bleeding but has not yet been shown to improve survival. OBJECTIVES This article reviews currently available agents for the… CONTINUE READING


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