Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal

@article{Shaham1995StressRH,
  title={Stress reinstates heroin-seeking in drug-free animals: An effect mimicking heroin, not withdrawal},
  author={Yavin Shaham and Jane Stewart},
  journal={Psychopharmacology},
  year={1995},
  volume={119},
  pages={334-341}
}
Exposure to 10 min of footshock stress (1 mA; 0.5 s on, with a mean off period of 40 s) reinstated heroin-seeking behavior in heroin-experienced, drug-free rats after many sessions of extinction and up to 6 weeks after last exposure to heroin. In reinstating the behavior, the footshock mimicked the effect of a non-contingent priming infusion of heroin (50 µg/kg). By contrast, the aversive state of acute opioid withdrawal induced by injection of the opioid receptor antagonist naltrexone (5 mg/kg… CONTINUE READING
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Classically conditioned factors in drug dependence

  • CP O'Brien
  • 1992

Conditioning factors in the relationship between stress and opioid self - administration in rats

  • Y Shaham
  • 1992

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