Stress proteins in glomerular epithelial cell injury.

  title={Stress proteins in glomerular epithelial cell injury.},
  author={Krikor Bijian and Andrey V Cybulsky},
  journal={Contributions to nephrology},
Glomerular visceral epithelial cells (GEC) or podocytes are highly differentiated, specialized cells that play a key role in the maintenance of glomerular permselectivity. Injury of GEC, leading to proteinuria, contributes to the pathogenesis of human and experimental glomerulopathies. Recent studies have demonstrated that stress proteins may be induced and may be involved in the modulation of GEC injury. The C5b-9 membrane attack complex of complement induces GEC injury and proteinuria in the… CONTINUE READING