Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation

@article{Horst2012StressON,
  title={Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation},
  author={Judith P. ter Horst and Maaike van der Mark and Mirko Arp and Sara Berger and Melly S. Oitzl},
  journal={Neurobiology of Learning and Memory},
  year={2012},
  volume={98},
  pages={33-40}
}
Corticosteroid effects on cognitive abilities during behavioral adaptation to stress are mediated by two types of receptors. While the glucocorticoid receptor (GR) is mainly involved in the consolidation of memory, the mineralocorticoid receptor (MR) mediates appraisal and initial responses to novelty. Recent findings in humans and mice suggest that under stress, the MR might be involved in the use of different learning strategies. Here, we used male mice lacking the MR in the forebrain (MR… CONTINUE READING

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