Stress models of depression: forming genetically vulnerable strains.

  title={Stress models of depression: forming genetically vulnerable strains.},
  author={Fritz A. Henn and Barbara Vollmayr},
  journal={Neuroscience and biobehavioral reviews},
  volume={29 4-5},
Among the most useful models for depressive disorders are those, which involve a stress induced change in behaviour. Learned helplessness is one such model and is induced through exposure to uncontrollable and unpredictable aversive events. Learned helplessness as induced in rats using foot shock is well characterized and has good face validity and predictive validity as a model of depression, including alterations in HPA axis activity and REM sleep characteristic of depression. The data… CONTINUE READING

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