Stress management at the ER: regulators of ER stress-induced apoptosis.

Abstract

The endoplasmic reticulum (ER) is an elaborate cellular organelle essential for cell function and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins which are detected by ER transmembrane receptors that initiate the unfolded protein response (UPR) to restore normal ER function. If the ER stress… (More)
DOI: 10.1016/j.pharmthera.2012.02.003

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