Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease

@article{Schfer2000StressKA,
  title={Stress kinases and heat shock proteins in the pancreas: possible roles in normal function and disease},
  author={Claus Sch{\"a}fer and John A. Williams},
  journal={Journal of Gastroenterology},
  year={2000},
  volume={35},
  pages={1-9}
}
Abstract: Mitogen-activated protein kinases (MAPKs) and heat shock proteins (Hsps) are ubiquitous proteins that function in both normal and stress-related pathophysiological states of the cell. Recent advances in the study of such Hsps and their interaction with signaling kinase cascades, including the cloning of new members, has helped to define their physiological roles in various tissues. In the pancreas, three major MAPKs, ERKs, JNKs, and p38, have been demonstrated. While intracellular… Expand
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References

SHOWING 1-10 OF 88 REFERENCES
Biological and Clinical Implications of Heat Shock Protein 27000 (Hsp27): a Review
TLDR
Studies suggest, however, that detection of Hsp27 should not be considered to be a method for identifying hormone-responsive tumors or detecting estrogen receptors, and HSP27 and other Hsps may be active in development of resistance to stressful conditions and agents including cytotoxic drugs. Expand
Heat shock proteins functioning as molecular chaperones: their roles in normal and stressed cells.
  • W. Welch
  • Biology, Medicine
  • Philosophical transactions of the Royal Society of London. Series B, Biological sciences
  • 1993
TLDR
The role of those stress proteins functioning as molecular chaperones, both within the normal cell and in the cell subjected to metabolic stress are discussed. Expand
Cholecystokinin stimulates heat shock protein 27 phosphorylation in rat pancreas both in vivo and in vitro.
TLDR
Hsp27 phosphorylation was stimulated by low and high concentrations of cholecystokinin, both in vivo and in vitro, and potentially mediated via the MAPKAP kinase 2 intracellular signaling pathway. Expand
Molecular cloning and characterization of human JNKK2, a novel Jun NH2-terminal kinase-specific kinase
TLDR
It is shown that JNKK2 is a highly specific JNK kinase, which may play somewhat different regulatory roles in a cell-type-dependent manner of mitogen-activated protein kinase cascades. Expand
Regulation of actin filament dynamics by p38 map kinase-mediated phosphorylation of heat shock protein 27.
TLDR
The results provide strong support to the idea that activation of p38 during adverse environmental conditions serves a homeostatic function aimed at regulating actin dynamics that would otherwise be destabilized during stress. Expand
Small Heat‐Shock Protein Family: Function in Health and Disease
TLDR
It was abundantly clear from results presented and from ensuing discussions in the workshop that the study of sHsps is an exceedingly dynamic area of research with an ever-expanding significance for a number of other areas of current biological research. Expand
Stress‐ and mitogen‐induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance.
TLDR
The results suggest that chaperone properties of the small heat shock proteins contribute to the increased cellular thermoresistance in a phosphorylation‐independent manner. Expand
Acute Pancreatitis Results in Induction of Heat Shock Proteins 70 and 27 and Heat Shock Factor-1
TLDR
It is concluded that acute pancreatitis results in a marked increase in the expression of HSP70 and HSP27 and may confer a protective effect for the remaining acini after acute Pancreasitis. Expand
Role of Mitogen-activated Protein Kinase Phosphatase during the Cellular Response to Genotoxic Stress
TLDR
Evidence is provided that MKP-1 plays a role in regulating transcriptional activation in response to UVC as well as another genotoxic agent, methyl methanesulfonate (MMS), and it is demonstrated that JNK is a likely target for MKp-1. Expand
Hyperthermia induces heat shock protein expression and protection against cerulein-induced pancreatitis in rats.
TLDR
A causal relation between hyperthermia-induced HSP expression and organ protection seems possible. Expand
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5
...