Stress induction of GRP78/BiP and its role in cancer.

@article{Li2006StressIO,
  title={Stress induction of GRP78/BiP and its role in cancer.},
  author={Jianze Li and Amy Si-Ying Lee},
  journal={Current molecular medicine},
  year={2006},
  volume={6 1},
  pages={
          45-54
        }
}
GRP78, also referred to as BiP, is a central regulator of endoplasmic reticulum (ER) function due to its roles in protein folding and assembly, targeting misfolded protein for degradation, ER Ca(2+)-binding and controlling the activation of trans-membrane ER stress sensors. Further, due to its anti-apoptotic property, stress induction of GRP78 represents an important pro-survival component of the unfolded protein response. GRP78 is induced in a wide variety of cancer cells and cancer biopsy… CONTINUE READING
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