Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress

@article{Deegan2012StressinducedSO,
  title={Stress-induced self-cannibalism: on the regulation of autophagy by endoplasmic reticulum stress},
  author={Shane Deegan and Svetlana Saveljeva and Adrienne M Gorman and Afshin Samali},
  journal={Cellular and Molecular Life Sciences},
  year={2012},
  volume={70},
  pages={2425-2441}
}
Macroautophagy (autophagy) is a cellular catabolic process which can be described as a self-cannibalism. It serves as an essential protective response during conditions of endoplasmic reticulum (ER) stress through the bulk removal and degradation of unfolded proteins and damaged organelles; in particular, mitochondria (mitophagy) and ER (reticulophagy). Autophagy is genetically regulated and the autophagic machinery facilitates removal of damaged cell components and proteins; however, if the… CONTINUE READING
78 Citations
154 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 78 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 154 references

Endoplasmic reticulum stress response mediated by the PERK-eIF2a-ATF4 pathway is involved in osteoblast differentiation induced by BMP2

  • A Saito
  • J Biol Chem 286:4809–4818
  • 2011
Highly Influential
17 Excerpts

Similar Papers

Loading similar papers…