Stress-induced relapse to heroin and cocaine seeking in rats: a review

@article{Shaham2000StressinducedRT,
  title={Stress-induced relapse to heroin and cocaine seeking in rats: a review},
  author={Yavin Shaham and Suzanne Erb and Jane Stewart},
  journal={Brain Research Reviews},
  year={2000},
  volume={33},
  pages={13-33}
}
Studies in humans suggest that exposure to stress increases the probability of relapse to drug use, but until recently there has been no animal model to study the mechanisms that mediate this effect. We have developed a reinstatement procedure that allows us to study the effect of stress on relapse to drug seeking in rats. Using this procedure, we have shown that exposure to intermittent footshock stress reliably reinstates heroin and cocaine seeking after prolonged drug-free periods. In the… CONTINUE READING
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Neurobiology of relapse to heroin and cocaine seeking: a review.

  • Pharmacological reviews
  • 2002
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The role of corticotropin-releasing factor in the median raphe nucleus in relapse to alcohol.

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