Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.

@article{Wohleb2013StressinducedRO,
  title={Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior.},
  author={Eric S. Wohleb and Nicole D. Powell and Jonathan P. Godbout and John F Sheridan},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2013},
  volume={33 34},
  pages={13820-33}
}
Social stress is associated with altered immunity and higher incidence of anxiety-related disorders. Repeated social defeat (RSD) is a murine stressor that primes peripheral myeloid cells, activates microglia, and induces anxiety-like behavior. Here we show that RSD-induced anxiety-like behavior corresponded with an exposure-dependent increase in circulating monocytes (CD11b(+)/SSC(lo)/Ly6C(hi)) and brain macrophages (CD11b(+)/SSC(lo)/CD45(hi)). Moreover, RSD-induced anxiety-like behavior… CONTINUE READING
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