Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy.

  title={Stress-induced premature senescence (SIPS)--influence of SIPS on radiotherapy.},
  author={Masatoshi Suzuki and David A. Boothman},
  journal={Journal of radiation research},
  volume={49 2},
Replicative senescence is a fundamental feature in normal human diploid cells and results from dysfunctional telomeres at the Hayflick cell division limit. Ionizing radiation (IR) prematurely induces the same phenotypes as replicative senescence prior to the Hayflick limit. This process is known as stress-induced premature senescence (SIPS). Since the cell cycle is irreversibly arrested in SIPS-induced cells, even if they are stimulated by various growth factors, it is thought that SIPS is a… CONTINUE READING


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