Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90.

@article{Pittet2005StressinducedIO,
  title={Stress-induced inhibition of the NF-kappaB signaling pathway results from the insolubilization of the IkappaB kinase complex following its dissociation from heat shock protein 90.},
  author={J F Pittet and Hyon Lee and Melissa H Pespeni and Allison O'Mahony and J{\'e}r{\'e}mie Roux and William J. Welch},
  journal={Journal of immunology},
  year={2005},
  volume={174 1},
  pages={
          384-94
        }
}
Activation of the stress response attenuates proinflammatory responses by suppressing cytokine-stimulated activation of the NF-kappaB signaling pathway. In this study, we show that the activation of the cellular stress response, either by heat shock treatment or after exposure to sodium arsenite, leads to a transient inhibition of IkappaBalpha phosphorylation. Inhibition of IkappaBalpha phosphorylation after stress was associated with the detergent insolubilization of the upstream kinases… CONTINUE READING
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