Stress-induced hyperthermia in mice: effects of flesinoxan on heart rate and body temperature.

@article{Bouwknecht2000StressinducedHI,
  title={Stress-induced hyperthermia in mice: effects of flesinoxan on heart rate and body temperature.},
  author={Jan Adriaan Bouwknecht and Theo H. Hijzen and Jan van der Gugten and Robert A. A. Maes and Berend Olivier},
  journal={European journal of pharmacology},
  year={2000},
  volume={400 1},
  pages={59-66}
}
Stress-induced hyperthermia in mice has predictive validity for anxiolytic properties of drugs. In this paradigm, 60 min after drug administration rectal temperature is measured, which causes hyperthermia of 1-1.5 degrees C (DeltaT) in about 10 min. Flesinoxan, a selective 5-HT(1A) receptor agonist with anxiolytic-like properties, causes hypothermia, which complicates interpretation of stress-induced hyperthermia. Therefore, we combined flesinoxan treatment and the stress paradigm with… CONTINUE READING