Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder

@article{Rau2005StressinducedEO,
  title={Stress-induced enhancement of fear learning: An animal model of posttraumatic stress disorder},
  author={V. Rau and J. Decola and M. Fanselow},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2005},
  volume={29},
  pages={1207-1223}
}
Fear is an adaptive response that initiates defensive behavior to protect animals and humans from danger. However, anxiety disorders, such as Posttraumatic Stress Disorder (PTSD), can occur when fear is inappropriately regulated. Fear conditioning can be used to study aspects of PTSD, and we have developed a model in which pre-exposure to a stressor of repeated footshock enhances conditional fear responding to a single context-shock pairing. The experiments in this chapter address… Expand
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