Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

  title={Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine},
  author={Boldizs{\'a}r Cz{\'e}h and Thomas Michaelis and Takashi Watanabe and Jens Frahm and Gabriel de Biurrun and Marja van Kampen and Alessandro Bartolomucci and Eberhard Fuchs},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  pages={12796 - 12801}
  • B. Czéh, T. Michaelis, E. Fuchs
  • Published 2 October 2001
  • Psychology, Biology
  • Proceedings of the National Academy of Sciences of the United States of America
Stress-induced structural remodeling in the adult hippocampus, involving debranching and shortening of dendrites and suppression of neurogenesis, provides a cellular basis for understanding the impairment of neural plasticity in the human hippocampus in depressive illness. Accordingly, reversal of structural remodeling may be a desirable goal for antidepressant therapy. The present study investigated the effect of tianeptine, a modified tricyclic antidepressant, in the chronic psychosocial… 

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