Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling

@inproceedings{Yabu2015StressinducedCG,
  title={Stress-induced ceramide generation and apoptosis via the phosphorylation and activation of nSMase1 by JNK signaling},
  author={Takeshi Yabu and Hajime Shiba and Yasuhiro Shibasaki and Tohru Nakanishi and Shintaro Imamura and Ken Touhata and Makiko Yamashita},
  booktitle={Cell Death and Differentiation},
  year={2015}
}
Neutral sphingomyelinase (nSMase) activation in response to environmental stress or inflammatory cytokine stimuli generates the second messenger ceramide, which mediates the stress-induced apoptosis. However, the signaling pathways and activation mechanism underlying this process have yet to be elucidated. Here we show that the phosphorylation of nSMase1 (sphingomyelin phosphodiesterase 2, SMPD2) by c-Jun N-terminal kinase (JNK) signaling stimulates ceramide generation and apoptosis and provide… CONTINUE READING