Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.

@article{Wang2004StressinducedAA,
  title={Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene.},
  author={Qingde Wang and Mana Miyakoda and Weidong Yang and Jaspal Singh Khillan and David L Stachura and Mitchell J Weiss and Kazuko Nishikura},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 6},
  pages={4952-61}
}
One type of RNA editing involves the conversion of adenosine residues into inosine in double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR). A-to-I RNA editing of the coding sequence could result in synthesis of proteins not directly encoded in the genome. ADAR edits also non-coding sequences of target RNAs, such as introns and 3'-untranslated regions, which may affect splicing, translation, and mRNA stability. Three mammalian ADAR gene family members (ADAR1-3… CONTINUE READING
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