Stress-induced Parkinson's disease: a working hypothesis.

  title={Stress-induced Parkinson's disease: a working hypothesis.},
  author={Amanda D. Smith and Sandra L. Castro and Michael J. Zigmond},
  journal={Physiology & behavior},
  volume={77 4-5},
Some cases of Parkinson's disease (PD) can be attributed to genetic mutations, others to specific environmental factors; yet the cause of a great majority of cases is unknown. Physical and emotional traumas were once briefly considered as factors in the pathophysiology of this disorder. With increasing evidence that stress can indeed increase neuronal loss in some brain regions, this hypothesis deserves to be reexamined. Stress increases the extracellular availability of glucocorticoids (GCs… CONTINUE READING
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