Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.

  title={Stress-induced CXCR4 promotes migration and invasion of ewing sarcoma.},
  author={Melanie Anne Krook and Lauren A. Nicholls and Christopher Scannell and Rashmi Chugh and Dafydd Gareth Thomas and Elizabeth R Lawlor},
  journal={Molecular cancer research : MCR},
  volume={12 6},
UNLABELLED Ewing sarcoma is the second most common bone cancer in pediatric patients. Although the primary cause of death in Ewing sarcoma is metastasis, the mechanism underlying tumor spread needs to be elucidated. To this end, the role of the CXCR4/SDF-1a chemokine axis as a mediator of Ewing sarcoma metastasis was investigated. CXCR4 expression status was measured in primary tumor specimens by immunohistochemical staining and in multiple cell lines by quantitative reverse transcriptase PCR… CONTINUE READING
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