Stress in pregnancy activates neurosteroid production in the fetal brain.

Abstract

Neurosteroids such as allopregnanolone are potent agonists at the GABA(A) receptor and suppress the fetal CNS activity. These steroids are synthesized in the fetal brain either from cholesterol or from circulating precursors derived from the placenta. The concentrations of allopregnanolone are remarkably high in the fetal brain and rise further in response… (More)

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Cite this paper

@article{Hirst2006StressIP, title={Stress in pregnancy activates neurosteroid production in the fetal brain.}, author={Jonathan J. Hirst and Tamara Yawno and Phuong Nguyen and David W. Walker}, journal={Neuroendocrinology}, year={2006}, volume={84 4}, pages={264-74} }