Stress in autoimmune disease models.

  title={Stress in autoimmune disease models.},
  author={Michael S. Harbuz and Louise J Richards and Anjo J Chover-Gonzalez and Octavi Mart{\'i}-Sistac and David S. Jessop},
  journal={Annals of the New York Academy of Sciences},
The release of endogenous glucocorticoids is critical in regulating the severity of disease activity in patients with inflammatory conditions such as rheumatoid arthritis (RA). Blocking cortisol production results in a flare-up in disease activity in RA patients, and surgical removal of the adrenals in patients with Cushing's disease has been reported to exacerbate autoimmune disease. In adjuvant-induced arthritis (AA; a rat model of RA), there is an activation of the hypothalamo-pituitary… CONTINUE READING

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