Stress habituation, body shape and cardiovascular mortality

@article{Peters2015StressHB,
  title={Stress habituation, body shape and cardiovascular mortality},
  author={Achim Peters and Bruce S. McEwen},
  journal={Neuroscience & Biobehavioral Reviews},
  year={2015},
  volume={56},
  pages={139-150}
}
High cardiovascular mortality is well documented in lean phenotypes exhibiting visceral fat accumulation. In contrast, corpulent phenotypes with predominantly subcutaneous fat accumulation display a surprisingly low mortality. The term 'obesity paradox' reflects the difficulty in understanding the biological mechanisms underlying these clinical observations. The allostatic load model of chronic stress focuses on glucocorticoid dysregulation as part of a 'network of allostasis' involving… CONTINUE READING
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