Stress granules and cell signaling: more than just a passing phase?

  title={Stress granules and cell signaling: more than just a passing phase?},
  author={Nancy L. Kedersha and Pavel Ivanov and Paul Anderson},
  journal={Trends in biochemical sciences},
  volume={38 10},
Stress granules (SGs) contain translationally-stalled mRNAs, associated preinitiation factors, and specific RNA-binding proteins. In addition, many signaling proteins are recruited to SGs and/or influence their assembly, which is transient, lasting only until the cells adapt to stress or die. Beyond their role as mRNA triage centers, we posit that SGs constitute RNA-centric signaling hubs analogous to classical multiprotein signaling domains such as transmembrane receptor complexes. As… CONTINUE READING
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