Stress granules: sites of mRNA triage that regulate mRNA stability and translatability.

@article{Kedersha2002StressGS,
  title={Stress granules: sites of mRNA triage that regulate mRNA stability and translatability.},
  author={Nancy Kedersha and P. Anderson},
  journal={Biochemical Society transactions},
  year={2002},
  volume={30 Pt 6},
  pages={
          963-9
        }
}
  • Nancy Kedersha, P. Anderson
  • Published in
    Biochemical Society…
    2002
  • Biology, Medicine
  • Mammalian stress granules (SGs) are cytoplasmic domains into which mRNAs are sorted dynamically in response to phosphorylation of eukaryotic initiation factor (eIF) 2alpha, a key regulatory step in translational initiation. The activation of one or more of the eIF2alpha kinases leads to SG assembly by decreasing the levels of eIF2-GTP-tRNA(Met), the ternary complex that is normally required for loading the initiator methionine onto the 48 S preinitiation complex to begin translation. This… CONTINUE READING

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    References

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    Translational Control of Gene Expression (Sonenberg

    • N. L. Kedersha, M. Gupta, W. Li, I. Miller, P. Anderson
    • J. Biol. Chern
    • 1999