Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation.

@article{Alexander2009StressEN,
  title={Stress exacerbates neuropathic pain via glucocorticoid and NMDA receptor activation.},
  author={Jessica K. Alexander and A Courtney Devries and Kristina A Kigerl and Jason M. Dahlman and Phillip G. Popovich},
  journal={Brain, behavior, and immunity},
  year={2009},
  volume={23 6},
  pages={851-60}
}
There is growing recognition that psychological stress influences pain. Hormones that comprise the physiological response to stress (e.g., corticosterone; CORT) may interact with effectors of neuropathic pain. To test this hypothesis, mice received a spared nerve injury (SNI) after exposure to 60 min restraint stress. In stressed mice, allodynia was consistently increased. The mechanism(s) underlying the exacerbated pain response involves CORT acting via glucocorticoid receptors (GRs); RU486, a… CONTINUE READING
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