Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus.

  title={Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus.},
  author={B A Stein-Behrens and Mark P. Mattson and Ihseop Chang and Ming – Chang Yeh and Robert Morris Sapolsky},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={14 9},
Glucocorticoids (GCs), the adrenal steroids secreted during stress, endanger the hippocampus, compromising its ability to survive neurological insults. GCs probably do so by disrupting energetics in the hippocampus, thus impairing its ability to contain damaging fluxes of excitatory amino acids and calcium. Superficially, these observations suggest that stress itself should also exacerbate the toxicity of neurological insults. However, most studies have involved unphysiologic GC manipulations… CONTINUE READING


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Stress induces atrophy of apical dendrites of hippocampal CA 3 neurons

M Weiner, S Volbach, D Svetlik
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