Stress during development: Impact on neuroplasticity and relevance to psychopathology

@article{Fumagalli2007StressDD,
  title={Stress during development: Impact on neuroplasticity and relevance to psychopathology},
  author={F. Fumagalli and R. Molteni and G. Racagni and M. Riva},
  journal={Progress in Neurobiology},
  year={2007},
  volume={81},
  pages={197-217}
}
Development represents a critical moment for shaping adult behavior and may set the stage to disease vulnerability later in life. There is now compelling evidence that stressful experiences during gestation or early in life can lead to enhanced susceptibility for mental illness. In this paper we review the data from experimental studies aimed at investigating behavioral, hormonal, functional and molecular consequences of exposure to stressful events during prenatal or early postnatal life that… Expand
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The major focus of the present chapter is to update and discuss data on behavioural, functional and morphological effects of prenatal stress in rats that may have counterparts in prospective and/or retrospective studies of gestational stress in humans. Expand
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It is shown that deviations from the gold standard trajectory of gut microbiota establishment and development in early life can lead not only to disorders of the gastrointestinal tract but also complex metabolic and immune disorders. Expand
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Experimental studies aimed to investigate hormonal, functional, molecular and epigenetic mechanisms involved in the stress response during early-life programming think these studies might prove useful for the identification of novel pharmacological targets for more effective treatments of mental disorders. Expand
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The results provide further support to the notion that exposure to early life stress has a negative impact on neuronal plasticity and that pharmacological intervention during critical time windows may prove effective in preventing neuroplastic dysfunction, leading to long-term beneficial effects on brain function. Expand
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The aim of this review is to examine the impacts of prenatal stress on developmental anatomy of the brain, particularly focusing on the relevant emotional and behavioural outcomes within the context of current data obtained from experimental animals. Expand
Effects of prenatal stress on developmental anatomy of the brain and adult behavioural pathology
During critical or sensitive periods of development, the brain is highly plastic and particularly vulnerable to environmental adverse effects, including stress. In response to gestational stress,… Expand
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TLDR
A well-established mouse model of prenatal stress (PRS) generated in restrained pregnant dams is introduced and PRS mice may serve as a useful model for investigating the pathogenesis of psychiatric disorders and may be a useful tool for screening for the potential compounds that may normalize aberrant epigenetic mechanisms induced by prenatal stress. Expand
Epigenetic marking of the BDNF gene by early-life adverse experiences
TLDR
At the center of the discussion is the brain-derived neurotrophic factor gene, as abnormal BDNF gene activity is a leading etiological hypothesis by which early-life adverse experiences persistently modify brain and behavioral plasticity. Expand
Annual Research Review: Epigenetic mechanisms and environmental shaping of the brain during sensitive periods of development.
  • T. Roth, J. Sweatt
  • Psychology, Medicine
  • Journal of child psychology and psychiatry, and allied disciplines
  • 2011
TLDR
Experiments in rodents continue to show that experiences during sensitive periods of development influence DNA methylation patterns of several genes, representing stable epigenetic modifications that alter gene transcription throughout the lifespan and promote specific behavioral outcomes. Expand
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