Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I

@inproceedings{Frantz2013StressdependentDC,
  title={Stress-dependent dilated cardiomyopathy in mice with cardiomyocyte-restricted inactivation of cyclic GMP-dependent protein kinase I},
  author={Stefan Frantz and Michael Klaiber and Hideo Baba and Heike Oberwinkler and Katharina Voelker and Birgit Gaβner and Barbara Bayer and Marco Abeβer and K Schuh and Robert Feil and Franz Hofmann and Michaela Kuhn},
  booktitle={European heart journal},
  year={2013}
}
AIMS Cardiac hypertrophy is a common and often lethal complication of arterial hypertension. Elevation of myocyte cyclic GMP levels by local actions of endogenous atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) or by pharmacological inhibition of phosphodiesterase-5 was shown to counter-regulate pathological hypertrophy. It was suggested that cGMP-dependent protein kinase I (cGKI) mediates this protective effect, although the role in vivo is under debate. Here, we… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 30 REFERENCES

Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2

M Klaiber, M Kruse, +13 authors M. Kuhn
  • Basic Res Cardiol 2010;5:583–595
  • 2010
VIEW 8 EXCERPTS
HIGHLY INFLUENTIAL

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics.

  • Pharmacology & therapeutics
  • 2009
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Atrial natriuretic peptide ameliorates peritoneal fibrosis in rat peritonitis model.

  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2012
VIEW 1 EXCERPT

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes.

  • Proceedings of the National Academy of Sciences of the United States of America
  • 2010
VIEW 2 EXCERPTS