Stress controls the mechanics of collagen networks.

  title={Stress controls the mechanics of collagen networks.},
  author={Albert James Licup and Stefan Muenster and Abhinav Sharma and Michael Sheinman and Louise M. Jawerth and Ben Fabry and David A. Weitz and Fred C MacKintosh},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={112 31},
Collagen is the main structural and load-bearing element of various connective tissues, where it forms the extracellular matrix that supports cells. It has long been known that collagenous tissues exhibit a highly nonlinear stress-strain relationship, although the origins of this nonlinearity remain unknown. Here, we show that the nonlinear stiffening of reconstituted type I collagen networks is controlled by the applied stress and that the network stiffness becomes surprisingly insensitive to… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.


Publications citing this paper.
Showing 1-10 of 37 extracted citations


Publications referenced by this paper.
Showing 1-10 of 48 references

Modeling semiflexible polymer networks

  • CP Broedersz, FC MacKintosh
  • Rev Mod Phys 86(3):995–1036
  • 2014
3 Excerpts

Similar Papers

Loading similar papers…