Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes

@inproceedings{Montan2014StressAT,
  title={Stress and the inflammatory process: a major cause of pancreatic cell death in type 2 diabetes},
  author={Joel Montan{\'e} and Lisa Cadavez and Anna Novials},
  booktitle={Diabetes, metabolic syndrome and obesity : targets and therapy},
  year={2014}
}
Type 2 diabetes (T2D) is a complex metabolic disorder characterized by hyperglycemia in the context of insulin resistance, which precedes insulin deficiency as a result of β-cell failure. Accumulating evidence indicates that β-cell loss in T2D results as a response to the combination of oxidative stress and endoplasmic reticulum (ER) stress. Failure of the ER's adaptive capacity and further activation of the unfolded protein response may trigger macroautophagy (hereafter referred as autophagy… CONTINUE READING

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