Stress and the brain: from adaptation to disease

  title={Stress and the brain: from adaptation to disease},
  author={E. R. Kloet and M. Jo{\"e}ls and F. Holsboer},
  journal={Nature Reviews Neuroscience},
  • E. R. Kloet, M. Joëls, F. Holsboer
  • Published 2005
  • Psychology, Chemistry, Medicine
  • Nature Reviews Neuroscience
  • In response to stress, the brain activates several neuropeptide-secreting systems. This eventually leads to the release of adrenal corticosteroid hormones, which subsequently feed back on the brain and bind to two types of nuclear receptor that act as transcriptional regulators. By targeting many genes, corticosteroids function in a binary fashion, and serve as a master switch in the control of neuronal and network responses that underlie behavioural adaptation. In genetically predisposed… CONTINUE READING
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    Stress hormone regulation: biological role and translation into therapy.
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    From vasotocin to stress and cognition
    • 12
    From vasotocin to stress and cognition.
    • E. D. de Kloet
    • Psychology, Medicine
    • European journal of pharmacology
    • 2010
    • 14
    Effects of stress hormones on the structure and function of the human brain
    • O. Wolf
    • Medicine
    • Expert review of endocrinology & metabolism
    • 2006
    • 37
    • PDF
    Learning about stress: neural, endocrine and behavioral adaptations
    • 45
    Brain development under stress: Hypotheses of glucocorticoid actions revisited
    • 312
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    • 354
    • PDF


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    • 78
    Corticotropin-Releasing Factor in Brain: A Role in Activation, Arousal, and Affect Regulation
    • 334
    Brain corticosteroid receptor balance in health and disease.
    • 2,411
    • PDF
    Mood disorders and allostatic load
    • B. McEwen
    • Psychology, Medicine
    • Biological Psychiatry
    • 2003
    • 918
    The Corticosteroid Receptor Hypothesis of Depression
    • F. Holsboer
    • Biology, Medicine
    • Neuropsychopharmacology
    • 2000
    • 1,941
    • PDF
    The stressed hippocampus, synaptic plasticity and lost memories
    • 1,244
    • PDF