Stress and hippocampal plasticity.

  title={Stress and hippocampal plasticity.},
  author={Bruce S. McEwen},
  journal={Annual review of neuroscience},
The hippocampus is a target of stress hormones, and it is an especially plastic and vulnerable region of the brain. It also responds to gonadal, thyroid, and adrenal hormones, which modulate changes in synapse formation and dendritic structure and regulate dentate gyrus volume during development and in adult life. Two forms of structural plasticity are affected by stress: Repeated stress causes atrophy of dendrites in the CA3 region, and both acute and chronic stress suppresses neurogenesis of… CONTINUE READING
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Chronic restraint stress alters synaptic terminal structure in hippocampus

  • AM Magarinos, JM Verdugo Garcia, BS. McEwen
  • Proc. Natl. Acad. Sci. USA94:14002–8
  • 1997
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Neurogenesis in the dentate gyrus of adult primates can be suppressed by stress.Soc

  • E Gould, P Tanapat, BS McEwen, G Flugge, E. Fuchs
  • 1997
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