Stress and glucocorticoids impair retrieval of long-term spatial memory

  title={Stress and glucocorticoids impair retrieval of long-term spatial memory},
  author={Dominique J.-F. de Quervain and Benno Roozendaal and J. D. McGaugh},
Extensive evidence from animal and human studies indicates that stress and glucocorticoids influence cognitive function. Previous studies have focused exclusively on glucocorticoid effects on acquisition and long-term storage of newly acquired information. Here we report that stress and glucocorticoids also affect memory retrieval. We show that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when… 

Glucocorticoids mediate stress-induced impairment of retrieval of stimulus-response memory

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The present findings suggest that the effect of stress on memory can be switched from impairment to enhancement dependent on both stress experience and age.

The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: Dependence on the basolateral amygdala

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lucocorticoids mediate stress-induced impairment of retrieval of timulus-response memory

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Sex differences in stress effects on response and spatial memory formation

Glucocorticoid Effects on Memory Retrieval Require Concurrent Noradrenergic Activity in the Hippocampus and Basolateral Amygdala

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Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.

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Glucocorticoid-induced impairment in declarative memory performance in adult humans

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Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity.

The results show that the cortisol response to anticipation of stress and to stress in the elderly specifically affects those memory functions that are dependent on hippocampal activity, and suggest that an altered cortisol responsivity to acute and/or chronic stress, with its detrimental effects on memory, could be an important factor explaining the genesis of memory deficits in aged populations.