Stress and glucocorticoids impair retrieval of long-term spatial memory

@article{deQuervain1998StressAG,
  title={Stress and glucocorticoids impair retrieval of long-term spatial memory},
  author={Dominique J.-F. de Quervain and Benno Roozendaal and J. D. McGaugh},
  journal={Nature},
  year={1998},
  volume={394},
  pages={787-790}
}
Extensive evidence from animal and human studies indicates that stress and glucocorticoids influence cognitive function. Previous studies have focused exclusively on glucocorticoid effects on acquisition and long-term storage of newly acquired information. Here we report that stress and glucocorticoids also affect memory retrieval. We show that rats have impaired performance in a water-maze spatial task after being given footshock 30 min before retention testing but are not impaired when… Expand
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References

SHOWING 1-10 OF 20 REFERENCES
Restraint stress reversibly enhances spatial memory performance
TLDR
The results suggest that the duration of stress may differentially affect learning/memory with shorter periods of stress serving an adaptive function while longer durations causing maladaptive changes. Expand
Experience‐dependent Facilitating Effect of Corticosterone on Spatial Memory Formation in the Water Maze
TLDR
This work indicates a facilitating corticosterone action, during the post‐training period, on the neural mechanisms determining the strength of information storage under acute, physiological conditions. Expand
Effects of chronic corticosterone ingestion on spatial memory performance and hippocampal serotonergic function
TLDR
The results suggest that hippocampal serotonergic terminals show long lasting effects from corticosterone and may also be an early indicator of deleterious effects of glucocorticoids on hippocampal function. Expand
Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine pretreatment.
TLDR
Results from Experiment 4 showed that chronic restraint stress impaired spatial memory performance on the Y maze when rats were tested the day after the last stress session and that tianeptine prevented the stress-induced spatial memory impairment. Expand
Glucocorticoid-induced impairment in declarative memory performance in adult humans
TLDR
Investigation of the cognitive consequences of DEX treatment in normal adult human subjects hypothesizing a decrease in declarative memory performance after extended but not overnight treatment found correct paragraph recall improved over the course of treatment, consistent with practice. Expand
Amygdaloid Nuclei Lesions Differentially Affect Glucocorticoid-Induced Memory Enhancement in an Inhibitory Avoidance Task
TLDR
Findings are consistent with previous evidence suggesting that the effects of glucocorticoids on memory storage are mediated by an activation of GRs, and indicate that the BLA and MEA nuclei are critical areas involved in integrating these hormonal influences on learning and memory. Expand
Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults.
TLDR
Elevated free cortisol levels are associated with impaired memory function in healthy adults, and subjects who received cortisol showed impairment in the declarative memory and spatial thinking tasks but not in the procedural memory task. Expand
The acute effects of corticosteroids on cognition: integration of animal and human model studies
TLDR
A theoretical framework is proposed that leads to testable predictions regarding the acute effects of corticosteroids on cognitive function and new experimental protocols for use in humans are suggested that could help resolve discrepancies and assess more clearly the nature of the cognitive deficits induced by acute administration of cortICosteroids. Expand
Dose-dependent suppression of adrenocortical activity with metyrapone: Effects on emotion and memory
TLDR
It is suggested that emotion, learning, and memory are differentially affected by the different doses of metyrapone due to interference with different types of adrenal steroid receptors and consequent induction of various corticosterone receptor states. Expand
Repeated stress causes reversible impairments of spatial memory performance
TLDR
These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs. Expand
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