Stress and dopamine: implications for the pathophysiology of chronic widespread pain.

@article{Wood2004StressAD,
  title={Stress and dopamine: implications for the pathophysiology of chronic widespread pain.},
  author={PhilipB. Wood},
  journal={Medical hypotheses},
  year={2004},
  volume={62 3},
  pages={
          420-4
        }
}
Fibromyalgia has been called a "stress-related disorder" due to the onset and exacerbation of symptoms in the context of stressful events. Evidence suggests that inhibition of tonic pain is mediated by activation of mesolimbic dopamine neurons, arising from the cell bodies of the ventral tegmental area and projecting to the nucleus accumbens. This pain-suppression system is activated by acute stress, via the release of endogenous opioids and substance P within the ventral tegmental area… CONTINUE READING

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