Stress and disorders of the stress system

@article{Chrousos2009StressAD,
  title={Stress and disorders of the stress system},
  author={George P. Chrousos},
  journal={Nature Reviews Endocrinology},
  year={2009},
  volume={5},
  pages={374-381}
}
  • G. Chrousos
  • Published 2 June 2009
  • Biology, Medicine
  • Nature Reviews Endocrinology
All organisms must maintain a complex dynamic equilibrium, or homeostasis, which is constantly challenged by internal or external adverse forces termed stressors. Stress occurs when homeostasis is threatened or perceived to be so; homeostasis is re-established by various physiological and behavioral adaptive responses. Neuroendocrine hormones have major roles in the regulation of both basal homeostasis and responses to threats, and are involved in the pathogenesis of diseases characterized by… 
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