Stress and disorders of the stress system

@article{Chrousos2009StressAD,
  title={Stress and disorders of the stress system},
  author={George P. Chrousos},
  journal={Nature Reviews Endocrinology},
  year={2009},
  volume={5},
  pages={374-381}
}
  • G. Chrousos
  • Published 2009
  • Biology, Medicine
  • Nature Reviews Endocrinology
All organisms must maintain a complex dynamic equilibrium, or homeostasis, which is constantly challenged by internal or external adverse forces termed stressors. Stress occurs when homeostasis is threatened or perceived to be so; homeostasis is re-established by various physiological and behavioral adaptive responses. Neuroendocrine hormones have major roles in the regulation of both basal homeostasis and responses to threats, and are involved in the pathogenesis of diseases characterized by… Expand

Paper Mentions

Observational Clinical Trial
In this project, the investigators will study a cohort of preterm infants, together with their parents, during NICU hospitalization and follow their developmental trajectory until… Expand
ConditionsPremature Birth of Newborn
Stress, the Stress System and the Role of Glucocorticoids
TLDR
The central and peripheral components of thestress system are described, a comprehensive overview of the stress response is provided, and the role of glucocorticoids in a broad spectrum of stress-related diseases is discussed. Expand
Stress, Endocrine Physiology and Pathophysiology - Endotext - NCBI Bookshelf
Stress is a state of threatened homeostasis caused by intrinsic or extrinsic adverse forces (stressors) and is counteracted by an intricate repertoir of physiologic and behavioral responses aiming toExpand
Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health
TLDR
The functional components of the two systems, their multilevel interactions, and how excessive or prolonged activity of the stress system affects the circadian rhythm of glucocorticoid secretion and target tissue effects are described. Expand
Stress Response and Child Health
TLDR
This review summarizes the topics presented at the fifth New Inroads to Child Health (NICHe) Conference “Stress Response and Child Health” held at Heraklion, Crete, Greece, in May 2012. Expand
The Corticotropin-Releasing Factor Family: Physiology of the Stress Response.
TLDR
This review focuses on the physiology of CRF-related peptides and their cognate receptors and describes the major molecular features covering aspects of gene expression and regulation, structural properties, and molecular interactions, as well as mechanisms of signal transduction and their surveillance. Expand
Neuro Endocrine Strategies during Adaptation to Stress
Stress is a state of threatened homeostasis caused by intrinsic or extrinsic adverse forces (stressors) and is counteracted by an intricate repertoire of physiologic and behavioral responses aimingExpand
Stress hormones: physiological stress and regulation of metabolism.
TLDR
Current data indicate that chronic stress, associated with mild hypercortisolemia and prolonged SNS activation, favors accumulation of visceral fat and contributes to the clinical presentation of visceral obesity, type 2 diabetes, and related cardiometabolic complications. Expand
Metabolic consequences of stress during childhood and adolescence.
TLDR
The understanding of stress mechanisms leading to metabolic abnormalities in early life may lead to more effective prevention and intervention strategies of obesity-related health problems. Expand
Adrenal Gland Microenvironment and Its Involvement in the Regulation of Stress-Induced Hormone Secretion during Sepsis
TLDR
Recent insights are highlighted into the understanding of the adrenal gland microenvironment and its role in coordination of stress-induced hormone secretion. Expand
The neuroendocrinology of stress: the stress-related continuum of chronic disease development
TLDR
A conceptual model of acute and chronic stress pathophysiology as a continuum in chronic disease development is discussed and a brief overview on the organization and physiology of the human stress system and its (re)activity is offered. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 186 REFERENCES
The Stress Response and Immune Function: Clinical Implications: The 1999 Novera H. Spector Lecture
  • G. Chrousos
  • Medicine
  • Annals of the New York Academy of Sciences
  • 2000
TLDR
There has been convincing evidence that corticotropin-releasing hormone (CRH), glucocorticoids, and CAs—as well as other products of the stress system—influence the immune response both at their baseline levels and/or at elevated levels observed during stress. Expand
Endocrinology of the stress response.
The stress response is subserved by the stress system, which is located both in the central nervous system and the periphery. The principal effectors of the stress system includeExpand
The role of stress and the hypothalamic–pituitary–adrenal axis in the pathogenesis of the metabolic syndrome: neuro-endocrine and target tissue-related causes
  • G. Chrousos
  • Medicine
  • International Journal of Obesity
  • 2000
TLDR
Stress-induced hypercortisolism and visceral obesity and their cardiovascular and other sequelae increase the all-cause mortality risk of affected subjects by 2–3-fold and curtail their life expectancy by several years. Expand
Pediatric Stress: Hormonal Mediators and Human Development
TLDR
The vulnerability of individuals to develop varying degrees and/or components of the above life-long syndrome is defined by as yet unidentified genetic factors, which account for up to 60% of the variance. Expand
Neuroendocrinology of stress.
TLDR
The promise of nonpeptide CRH type-1 receptor antagonists to directly target the stress system in the brain is highlighted and the implications of aberrant stress system activity on physical and mental health are outlined. Expand
Mechanisms of Physical and Emotional Stress
The Concept of Stress and Its Historical Development.- Basic Mechanisms of the Stress Response.- Sympathoadrenal Medullary System and Stress.- Behavioral Pharmacology of Stress: Focus on CNSExpand
Glucocorticoid action networks and complex psychiatric and/or somatic disorders
TLDR
The conception that glucocorticoids are heavily involved in human pathophysiology and influence life expectancy is presented. Expand
Psychological stress increased corticotropin-releasing hormone mRNA and content in the central nucleus of the amygdala but not in the hypothalamic paraventricular nucleus in the rat
TLDR
The data suggest that CRH in the CEA may contribute to the psychological stress-evoked fear-related behavior such as hyperarousal and indicate that in response to a psychological stressor, the amygdala CRH system is much more sensitive than is theCRH system emanating from the PVN. Expand
Sleep, the hypothalamic-pituitary-adrenal axis, and cytokines: multiple interactions and disturbances in sleep disorders.
TLDR
Findings suggest that the HPA axis stimulates arousal, while IL-6 and TNF-alpha are possible mediators of excessive daytime sleepiness in humans. Expand
The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis.
TLDR
The notion of a stress system as the effector of the stress syndrome is suggested, and its physiologic and pathophysiologic manifestations are described, to allow generation and testing of new hypotheses on the pathophysiology and diagnosis of, and therapy for, a variety of human illnesses. Expand
...
1
2
3
4
5
...