Stress and cognition: are corticosteroids good or bad guys?

  title={Stress and cognition: are corticosteroids good or bad guys?},
  author={Edo Ronald de Kloet and Melly S. Oitzl and Marian Jo{\"e}ls},
  journal={Trends in neurosciences},
  volume={22 10},
Corticosteroid hormones secreted by the adrenal cortex protect the brain against adverse events and are essential for cognitive performance. However, in recent literature, the central action of corticosteroids has mostly been portrayed as damaging and disruptive to memory formation. We argue that this paradox can be explained by appreciating the specific role of both mineralocorticoid and glucocorticoid receptors in the various stages of information processing. In addition, the context in which… CONTINUE READING
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