Stress and Epilepsy: Multiple Models, Multiple Outcomes

  title={Stress and Epilepsy: Multiple Models, Multiple Outcomes},
  author={Nikki T. Sawyer and Andrew Escayg},
  journal={Journal of Clinical Neurophysiology},
Human studies show a link between stress and epilepsy, with stress causing an increase in seizure frequency and severity in patients with epilepsy. Many different animal model systems have been used to better understand this connection and the possible mechanisms involved. This review highlights the results of such studies relating stress and seizure susceptibility, with a focus on the hypothalamic-pituitary-adrenal axis and its relationship to seizure generation. The effects of hypothalamic… 

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