Stress alters cutaneous permeability barrier homeostasis.

  title={Stress alters cutaneous permeability barrier homeostasis.},
  author={Mitsuhiro Denda and Toru Tsuchiya and Peter M. Elias and Kenneth R. Feingold},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  volume={278 2},
  • M. DendaT. Tsuchiya K. Feingold
  • Published 1 February 2000
  • Biology, Psychology
  • American journal of physiology. Regulatory, integrative and comparative physiology
Recent studies have shown that psychological stress can influence cutaneous barrier function, suggesting that this form of stress could trigger or aggravate skin disease. In the present study, we demonstrate that transfer of hairless mice to a different cage delays barrier recovery rates. Pretreatment with a phenothiazine sedative, chlorpromazine, before transfer of animals restored the kinetics of barrier recovery toward normal, suggesting that psychological stress is the basis for this… 

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